diff --git a/ddl/partition.go b/ddl/partition.go
index ef81b7da5b..b9d0d72d91 100644
--- a/ddl/partition.go
+++ b/ddl/partition.go
@@ -130,7 +130,7 @@ func (w *worker) onAddTablePartition(d *ddlCtx, t *meta.Meta, job *model.Job) (v
 			return ver, errors.Trace(err)
 		}
 
-		if err = infosync.PutRuleBundles(context.TODO(), bundles); err != nil {
+		if err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), bundles); err != nil {
 			job.State = model.JobStateCancelled
 			return ver, errors.Wrapf(err, "failed to notify PD the placement rules")
 		}
@@ -1040,7 +1040,7 @@ func (w *worker) onDropTablePartition(d *ddlCtx, t *meta.Meta, job *model.Job) (
 	if job.Type == model.ActionAddTablePartition {
 		// It is rollbacked from adding table partition, just remove addingDefinitions from tableInfo.
 		physicalTableIDs, pNames, rollbackBundles := rollbackAddingPartitionInfo(tblInfo)
-		err = infosync.PutRuleBundles(context.TODO(), rollbackBundles)
+		err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), rollbackBundles)
 		if err != nil {
 			job.State = model.JobStateCancelled
 			return ver, errors.Wrapf(err, "failed to notify PD the placement rules")
@@ -1208,7 +1208,7 @@ func onTruncateTablePartition(d *ddlCtx, t *meta.Meta, job *model.Job) (int64, e
 		return ver, errors.Trace(err)
 	}
 
-	err = infosync.PutRuleBundles(context.TODO(), bundles)
+	err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), bundles)
 	if err != nil {
 		job.State = model.JobStateCancelled
 		return ver, errors.Wrapf(err, "failed to notify PD the placement rules")
@@ -1412,7 +1412,7 @@ func (w *worker) onExchangeTablePartition(d *ddlCtx, t *meta.Meta, job *model.Jo
 		return ver, errors.Trace(err)
 	}
 
-	if err = infosync.PutRuleBundles(context.TODO(), bundles); err != nil {
+	if err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), bundles); err != nil {
 		job.State = model.JobStateCancelled
 		return ver, errors.Wrapf(err, "failed to notify PD the placement rules")
 	}
diff --git a/ddl/placement_policy.go b/ddl/placement_policy.go
index 0fcd17270c..65a445ca62 100644
--- a/ddl/placement_policy.go
+++ b/ddl/placement_policy.go
@@ -262,7 +262,7 @@ func onAlterPlacementPolicy(d *ddlCtx, t *meta.Meta, job *model.Job) (ver int64,
 			cp := bundle.Clone()
 			bundles = append(bundles, cp.Reset(placement.RuleIndexPartition, []int64{id}))
 		}
-		err = infosync.PutRuleBundles(context.TODO(), bundles)
+		err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), bundles)
 		if err != nil {
 			job.State = model.JobStateCancelled
 			return ver, errors.Wrapf(err, "failed to notify PD the placement rules")
diff --git a/ddl/table.go b/ddl/table.go
index c2f217fc6e..906db66f3a 100644
--- a/ddl/table.go
+++ b/ddl/table.go
@@ -101,7 +101,7 @@ func onCreateTable(d *ddlCtx, t *meta.Meta, job *model.Job) (ver int64, _ error)
 		}
 
 		// Send the placement bundle to PD.
-		err = infosync.PutRuleBundles(context.TODO(), bundles)
+		err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), bundles)
 		if err != nil {
 			job.State = model.JobStateCancelled
 			return ver, errors.Wrapf(err, "failed to notify PD the placement rules")
@@ -580,7 +580,7 @@ func onTruncateTable(d *ddlCtx, t *meta.Meta, job *model.Job) (ver int64, _ erro
 		return ver, errors.Trace(err)
 	}
 
-	err = infosync.PutRuleBundles(context.TODO(), bundles)
+	err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), bundles)
 	if err != nil {
 		job.State = model.JobStateCancelled
 		return 0, errors.Wrapf(err, "failed to notify PD the placement rules")
@@ -1302,7 +1302,7 @@ func onAlterTablePartitionOptions(d *ddlCtx, t *meta.Meta, job *model.Job) (ver
 
 	// Send the placement bundle to PD.
 	if bundle != nil {
-		err = infosync.PutRuleBundles(context.TODO(), []*placement.Bundle{bundle})
+		err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), []*placement.Bundle{bundle})
 	}
 
 	if err != nil {
@@ -1353,7 +1353,7 @@ func onAlterTablePlacement(d *ddlCtx, t *meta.Meta, job *model.Job) (ver int64,
 
 	// Send the placement bundle to PD.
 	if bundle != nil {
-		err = infosync.PutRuleBundles(context.TODO(), []*placement.Bundle{bundle})
+		err = infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), []*placement.Bundle{bundle})
 	}
 
 	if err != nil {
diff --git a/domain/infosync/error.go b/domain/infosync/error.go
new file mode 100644
index 0000000000..53c1fedcd9
--- /dev/null
+++ b/domain/infosync/error.go
@@ -0,0 +1,28 @@
+// Copyright 2021 PingCAP, Inc.
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+package infosync
+
+import (
+	"github.com/pingcap/tidb/errno"
+	"github.com/pingcap/tidb/parser/mysql"
+	"github.com/pingcap/tidb/util/dbterror"
+)
+
+var (
+	// ErrHTTPServiceError means we got a http response with a status code which is not '2xx'
+	ErrHTTPServiceError = dbterror.ClassDomain.NewStdErr(
+		errno.ErrHTTPServiceError, mysql.Message("HTTP request failed with status %s", nil),
+	)
+)
diff --git a/domain/infosync/info.go b/domain/infosync/info.go
index 26bd49d57e..fc58783ff3 100644
--- a/domain/infosync/info.go
+++ b/domain/infosync/info.go
@@ -80,6 +80,10 @@ const (
 	TopologyPrometheus = "/topology/prometheus"
 	// TablePrometheusCacheExpiry is the expiry time for prometheus address cache.
 	TablePrometheusCacheExpiry = 10 * time.Second
+	// RequestRetryInterval is the sleep time before next retry for http request
+	RequestRetryInterval = 200 * time.Millisecond
+	// SyncBundlesMaxRetry is the max retry times for sync placement bundles
+	SyncBundlesMaxRetry = 3
 )
 
 // ErrPrometheusAddrIsNotSet is the error that Prometheus address is not set in PD and etcd
@@ -353,7 +357,7 @@ func doRequest(ctx context.Context, addrs []string, route, method string, body i
 				return nil, err
 			}
 			if res.StatusCode != http.StatusOK {
-				err = errors.Errorf("%s", bodyBytes)
+				err = ErrHTTPServiceError.FastGen("%s", bodyBytes)
 				if res.StatusCode == http.StatusNotFound || res.StatusCode == http.StatusPreconditionFailed {
 					err = nil
 					bodyBytes = nil
@@ -427,6 +431,16 @@ func GetRuleBundle(ctx context.Context, name string) (*placement.Bundle, error)
 
 // PutRuleBundles is used to post specific rule bundles to PD.
 func PutRuleBundles(ctx context.Context, bundles []*placement.Bundle) error {
+	failpoint.Inject("putRuleBundlesError", func(isServiceError failpoint.Value) {
+		var err error
+		if isServiceError.(bool) {
+			err = ErrHTTPServiceError.FastGen("mock service error")
+		} else {
+			err = errors.New("mock other error")
+		}
+		failpoint.Return(err)
+	})
+
 	is, err := getGlobalInfoSyncer()
 	if err != nil {
 		return err
@@ -435,6 +449,31 @@ func PutRuleBundles(ctx context.Context, bundles []*placement.Bundle) error {
 	return is.placementManager.PutRuleBundles(ctx, bundles)
 }
 
+// PutRuleBundlesWithRetry will retry for specified times when PutRuleBundles failed
+func PutRuleBundlesWithRetry(ctx context.Context, bundles []*placement.Bundle, maxRetry int, interval time.Duration) (err error) {
+	if maxRetry < 0 {
+		maxRetry = 0
+	}
+
+	for i := 0; i <= maxRetry; i++ {
+		if err = PutRuleBundles(ctx, bundles); err == nil || ErrHTTPServiceError.Equal(err) {
+			return err
+		}
+
+		if i != maxRetry {
+			logutil.BgLogger().Warn("Error occurs when PutRuleBundles, retry", zap.Error(err))
+			time.Sleep(interval)
+		}
+	}
+
+	return
+}
+
+// PutRuleBundlesWithDefaultRetry will retry for default times
+func PutRuleBundlesWithDefaultRetry(ctx context.Context, bundles []*placement.Bundle) (err error) {
+	return PutRuleBundlesWithRetry(ctx, bundles, SyncBundlesMaxRetry, RequestRetryInterval)
+}
+
 func (is *InfoSyncer) getAllServerInfo(ctx context.Context) (map[string]*ServerInfo, error) {
 	allInfo := make(map[string]*ServerInfo)
 	if is.etcdCli == nil {
diff --git a/domain/infosync/info_test.go b/domain/infosync/info_test.go
index e839b5daa8..001a106632 100644
--- a/domain/infosync/info_test.go
+++ b/domain/infosync/info_test.go
@@ -26,8 +26,10 @@ import (
 	"time"
 
 	"github.com/pingcap/failpoint"
+	"github.com/pingcap/tidb/ddl/placement"
 	"github.com/pingcap/tidb/ddl/util"
 	"github.com/pingcap/tidb/owner"
+	"github.com/pingcap/tidb/parser/model"
 	"github.com/pingcap/tidb/util/testbridge"
 	"github.com/stretchr/testify/require"
 	"go.etcd.io/etcd/integration"
@@ -145,3 +147,66 @@ func (is *InfoSyncer) ttlKeyExists(ctx context.Context) (bool, error) {
 	}
 	return len(resp.Kvs) == 1, nil
 }
+
+func TestPutBundlesRetry(t *testing.T) {
+	_, err := GlobalInfoSyncerInit(context.TODO(), "test", func() uint64 { return 1 }, nil, false)
+	require.NoError(t, err)
+
+	bundle, err := placement.NewBundleFromOptions(&model.PlacementSettings{PrimaryRegion: "r1", Regions: "r1,r2"})
+	require.NoError(t, err)
+	bundle = bundle.Reset(placement.RuleIndexTable, []int64{1024})
+
+	t.Run("serviceErrorShouldNotRetry", func(t *testing.T) {
+		require.NoError(t, PutRuleBundles(context.TODO(), []*placement.Bundle{{ID: bundle.ID}}))
+		require.NoError(t, failpoint.Enable("github.com/pingcap/tidb/domain/infosync/putRuleBundlesError", "1*return(true)"))
+		defer func() {
+			require.NoError(t, failpoint.Disable("github.com/pingcap/tidb/domain/infosync/putRuleBundlesError"))
+		}()
+
+		err := PutRuleBundlesWithRetry(context.TODO(), []*placement.Bundle{bundle}, 3, time.Millisecond)
+		require.Error(t, err)
+		require.Equal(t, "[domain:8243]mock service error", err.Error())
+
+		got, err := GetRuleBundle(context.TODO(), bundle.ID)
+		require.NoError(t, err)
+		require.True(t, got.IsEmpty())
+	})
+
+	t.Run("nonServiceErrorShouldRetry", func(t *testing.T) {
+		require.NoError(t, PutRuleBundles(context.TODO(), []*placement.Bundle{{ID: bundle.ID}}))
+		require.NoError(t, failpoint.Enable("github.com/pingcap/tidb/domain/infosync/putRuleBundlesError", "3*return(false)"))
+		defer func() {
+			require.NoError(t, failpoint.Disable("github.com/pingcap/tidb/domain/infosync/putRuleBundlesError"))
+		}()
+
+		err := PutRuleBundlesWithRetry(context.TODO(), []*placement.Bundle{bundle}, 3, time.Millisecond)
+		require.NoError(t, err)
+
+		got, err := GetRuleBundle(context.TODO(), bundle.ID)
+		require.NoError(t, err)
+
+		gotJSON, err := json.Marshal(got)
+		require.NoError(t, err)
+
+		expectJSON, err := json.Marshal(bundle)
+		require.NoError(t, err)
+
+		require.Equal(t, expectJSON, gotJSON)
+	})
+
+	t.Run("nonServiceErrorRetryAndFail", func(t *testing.T) {
+		require.NoError(t, PutRuleBundles(context.TODO(), []*placement.Bundle{{ID: bundle.ID}}))
+		require.NoError(t, failpoint.Enable("github.com/pingcap/tidb/domain/infosync/putRuleBundlesError", "4*return(false)"))
+		defer func() {
+			require.NoError(t, failpoint.Disable("github.com/pingcap/tidb/domain/infosync/putRuleBundlesError"))
+		}()
+
+		err := PutRuleBundlesWithRetry(context.TODO(), []*placement.Bundle{bundle}, 3, time.Millisecond)
+		require.Error(t, err)
+		require.Equal(t, "mock other error", err.Error())
+
+		got, err := GetRuleBundle(context.TODO(), bundle.ID)
+		require.NoError(t, err)
+		require.True(t, got.IsEmpty())
+	})
+}
diff --git a/errno/errcode.go b/errno/errcode.go
index e0c5f7cccb..ea1fb86ea7 100644
--- a/errno/errcode.go
+++ b/errno/errcode.go
@@ -1055,6 +1055,7 @@ const (
 	ErrPlacementPolicyWithDirectOption    = 8240
 	ErrPlacementPolicyInUse               = 8241
 	ErrOptOnCacheTable                    = 8242
+	ErrHTTPServiceError                   = 8243
 	// TiKV/PD/TiFlash errors.
 	ErrPDServerTimeout           = 9001
 	ErrTiKVServerTimeout         = 9002
diff --git a/errors.toml b/errors.toml
index 0f27a704f6..8709460393 100644
--- a/errors.toml
+++ b/errors.toml
@@ -726,6 +726,11 @@ error = '''
 Information schema is changed during the execution of the statement(for example, table definition may be updated by other DDL ran in parallel). If you see this error often, try increasing `tidb_max_delta_schema_count`. [try again later]
 '''
 
+["domain:8243"]
+error = '''
+HTTP request failed with status %s
+'''
+
 ["domain:9009"]
 error = '''
 Prometheus address is not set in PD and etcd
diff --git a/store/gcworker/gc_worker.go b/store/gcworker/gc_worker.go
index e238c85ee2..854408f082 100644
--- a/store/gcworker/gc_worker.go
+++ b/store/gcworker/gc_worker.go
@@ -1914,7 +1914,7 @@ func (w *GCWorker) doGCPlacementRules(dr util.DelRangeTask) (err error) {
 	for _, id := range physicalTableIDs {
 		bundles = append(bundles, placement.NewBundle(id))
 	}
-	return infosync.PutRuleBundles(context.TODO(), bundles)
+	return infosync.PutRuleBundlesWithDefaultRetry(context.TODO(), bundles)
 }
 
 func (w *GCWorker) doGCLabelRules(dr util.DelRangeTask) (err error) {