diff --git a/store/tikv/commit.go b/store/tikv/commit.go
index 449081860c..10c60d9f6d 100644
--- a/store/tikv/commit.go
+++ b/store/tikv/commit.go
@@ -48,7 +48,7 @@ func (actionCommit) handleSingleBatch(c *twoPhaseCommitter, bo *Backoffer, batch
 		CommitVersion: c.commitTS,
 	}, pb.Context{Priority: c.priority, SyncLog: c.syncLog})
 
-	sender := NewRegionRequestSender(c.store.regionCache, c.store.client)
+	sender := NewRegionRequestSender(c.store.regionCache, c.store.GetTiKVClient())
 	resp, err := sender.SendReq(bo, req, batch.region, ReadTimeoutShort)
 
 	// If we fail to receive response for the request that commits primary key, it will be undetermined whether this
diff --git a/store/tikv/kv.go b/store/tikv/kv.go
index f61db4168e..bbf8517a42 100644
--- a/store/tikv/kv.go
+++ b/store/tikv/kv.go
@@ -66,10 +66,13 @@ var oracleUpdateInterval = 2000
 
 // KVStore contains methods to interact with a TiKV cluster.
 type KVStore struct {
-	clusterID    uint64
-	uuid         string
-	oracle       oracle.Oracle
-	client       Client
+	clusterID uint64
+	uuid      string
+	oracle    oracle.Oracle
+	clientMu  struct {
+		sync.RWMutex
+		client Client
+	}
 	pdClient     pd.Client
 	regionCache  *RegionCache
 	lockResolver *LockResolver
@@ -133,7 +136,6 @@ func NewKVStore(uuid string, pdClient pd.Client, spkv SafePointKV, client Client
 		clusterID:       pdClient.GetClusterID(context.TODO()),
 		uuid:            uuid,
 		oracle:          o,
-		client:          reqCollapse{client},
 		pdClient:        pdClient,
 		regionCache:     NewRegionCache(pdClient),
 		kv:              spkv,
@@ -142,6 +144,7 @@ func NewKVStore(uuid string, pdClient pd.Client, spkv SafePointKV, client Client
 		closed:          make(chan struct{}),
 		replicaReadSeed: rand.Uint32(),
 	}
+	store.clientMu.client = reqCollapse{client}
 	store.lockResolver = newLockResolver(store)
 
 	go store.runSafePointChecker()
@@ -205,7 +208,7 @@ func (s *KVStore) Close() error {
 	s.pdClient.Close()
 
 	close(s.closed)
-	if err := s.client.Close(); err != nil {
+	if err := s.GetTiKVClient().Close(); err != nil {
 		return errors.Trace(err)
 	}
 
@@ -312,7 +315,7 @@ func (s *KVStore) SupportDeleteRange() (supported bool) {
 
 // SendReq sends a request to region.
 func (s *KVStore) SendReq(bo *Backoffer, req *tikvrpc.Request, regionID RegionVerID, timeout time.Duration) (*tikvrpc.Response, error) {
-	sender := NewRegionRequestSender(s.regionCache, s.client)
+	sender := NewRegionRequestSender(s.regionCache, s.GetTiKVClient())
 	return sender.SendReq(bo, req, regionID, timeout)
 }
 
@@ -343,12 +346,16 @@ func (s *KVStore) SetOracle(oracle oracle.Oracle) {
 
 // SetTiKVClient resets the client instance.
 func (s *KVStore) SetTiKVClient(client Client) {
-	s.client = client
+	s.clientMu.Lock()
+	defer s.clientMu.Unlock()
+	s.clientMu.client = client
 }
 
 // GetTiKVClient gets the client instance.
 func (s *KVStore) GetTiKVClient() (client Client) {
-	return s.client
+	s.clientMu.RLock()
+	defer s.clientMu.RUnlock()
+	return s.clientMu.client
 }
 
 func (s *KVStore) getSafeTS(storeID uint64) uint64 {
diff --git a/store/tikv/prewrite.go b/store/tikv/prewrite.go
index 7097ba5dbc..ffb47e1fb4 100644
--- a/store/tikv/prewrite.go
+++ b/store/tikv/prewrite.go
@@ -157,7 +157,7 @@ func (action actionPrewrite) handleSingleBatch(c *twoPhaseCommitter, bo *Backoff
 
 	req := c.buildPrewriteRequest(batch, txnSize)
 	for {
-		sender := NewRegionRequestSender(c.store.regionCache, c.store.client)
+		sender := NewRegionRequestSender(c.store.regionCache, c.store.GetTiKVClient())
 		resp, err := sender.SendReq(bo, req, batch.region, ReadTimeoutShort)
 
 		// If we fail to receive response for async commit prewrite, it will be undetermined whether this
diff --git a/store/tikv/scan.go b/store/tikv/scan.go
index 6c43b7bdee..035291a783 100644
--- a/store/tikv/scan.go
+++ b/store/tikv/scan.go
@@ -164,7 +164,7 @@ func (s *Scanner) getData(bo *Backoffer) error {
 		zap.String("nextEndKey", kv.StrKey(s.nextEndKey)),
 		zap.Bool("reverse", s.reverse),
 		zap.Uint64("txnStartTS", s.startTS()))
-	sender := NewRegionRequestSender(s.snapshot.store.regionCache, s.snapshot.store.client)
+	sender := NewRegionRequestSender(s.snapshot.store.regionCache, s.snapshot.store.GetTiKVClient())
 	var reqEndKey, reqStartKey []byte
 	var loc *KeyLocation
 	var err error
diff --git a/store/tikv/split_region.go b/store/tikv/split_region.go
index 38ce24917d..c33a89efc1 100644
--- a/store/tikv/split_region.go
+++ b/store/tikv/split_region.go
@@ -123,7 +123,7 @@ func (s *KVStore) batchSendSingleRegion(bo *Backoffer, batch batch, scatter bool
 		Priority: kvrpcpb.CommandPri_Normal,
 	})
 
-	sender := NewRegionRequestSender(s.regionCache, s.client)
+	sender := NewRegionRequestSender(s.regionCache, s.GetTiKVClient())
 	resp, err := sender.SendReq(bo, req, batch.regionID, ReadTimeoutShort)
 
 	batchResp := singleBatchResp{resp: resp}