diff --git a/.vpython3 b/.vpython3
new file mode 100644
index 0000000000..17de513da7
--- /dev/null
+++ b/.vpython3
@@ -0,0 +1,76 @@
+# This is a vpython "spec" file.
+#
+# It describes patterns for python wheel dependencies of the python scripts in
+# the chromium repo, particularly for dependencies that have compiled components
+# (since pure-python dependencies can be easily vendored into third_party).
+#
+# When vpython is invoked, it finds this file and builds a python VirtualEnv,
+# containing all of the dependencies described in this file, fetching them from
+# CIPD (the "Chrome Infrastructure Package Deployer" service). Unlike `pip`,
+# this never requires the end-user machine to have a working python extension
+# compilation environment. All of these packages are built using:
+#   https://chromium.googlesource.com/infra/infra/+/main/infra/tools/dockerbuild/
+#
+# All python scripts in the repo share this same spec, to avoid dependency
+# fragmentation.
+#
+# If you have depot_tools installed in your $PATH, you can invoke python scripts
+# in this repo by running them as you normally would run them, except
+# substituting `vpython` instead of `python` on the command line, e.g.:
+#   vpython path/to/script.py some --arguments
+#
+# Read more about `vpython` and how to modify this file here:
+#   https://chromium.googlesource.com/infra/infra/+/main/doc/users/vpython.md
+
+python_version: "3.8"
+
+# Used by:
+#   third_party/catapult
+wheel: <
+  name: "infra/python/wheels/psutil/${platform}_${py_python}_${py_abi}"
+  version: "version:5.2.2"
+>
+
+# Used by tools_webrtc/perf/webrtc_dashboard_upload.py.
+wheel: <
+  name: "infra/python/wheels/httplib2-py2_py3"
+  version: "version:0.10.3"
+>
+
+# Used by:
+#   build/toolchain/win
+wheel: <
+  name: "infra/python/wheels/pypiwin32/${vpython_platform}"
+  version: "version:219"
+  match_tag: <
+    platform: "win32"
+  >
+  match_tag: <
+    platform: "win_amd64"
+  >
+>
+
+wheel: <
+  name: "infra/python/wheels/six-py2_py3"
+  version: "version:1.15.0"
+>
+wheel: <
+  name: "infra/python/wheels/pbr-py2_py3"
+  version: "version:3.0.0"
+>
+wheel: <
+  name: "infra/python/wheels/funcsigs-py2_py3"
+  version: "version:1.0.2"
+>
+wheel: <
+  name: "infra/python/wheels/mock-py2_py3"
+  version: "version:2.0.0"
+>
+wheel: <
+  name: "infra/python/wheels/protobuf-py2_py3"
+  version: "version:3.13.0"
+>
+wheel: <
+  name: "infra/python/wheels/requests-py2_py3"
+  version: "version:2.13.0"
+>
diff --git a/OWNERS b/OWNERS
index 98eef283b7..ac801fe699 100644
--- a/OWNERS
+++ b/OWNERS
@@ -10,6 +10,7 @@ per-file .../BUILD.gn=mbonadei@webrtc.org
 per-file *.gni=mbonadei@webrtc.org
 per-file .../*.gni=mbonadei@webrtc.org
 per-file .vpython=mbonadei@webrtc.org
+per-file .vpython3=mbonadei@webrtc.org
 per-file AUTHORS=*
 per-file DEPS=*
 per-file pylintrc=mbonadei@webrtc.org