diff --git a/modules/rtp_rtcp/source/time_util.h b/modules/rtp_rtcp/source/time_util.h
index 5e72bba3b9..9ff444b12e 100644
--- a/modules/rtp_rtcp/source/time_util.h
+++ b/modules/rtp_rtcp/source/time_util.h
@@ -14,6 +14,7 @@
 #include <stdint.h>
 
 #include "api/units/time_delta.h"
+#include "rtc_base/numerics/safe_conversions.h"
 #include "system_wrappers/include/ntp_time.h"
 
 namespace webrtc {
@@ -35,11 +36,14 @@ inline uint32_t CompactNtp(NtpTime ntp) {
 uint32_t SaturatedToCompactNtp(TimeDelta delta);
 
 // Convert interval to the NTP time resolution (1/2^32 seconds ~= 0.2 ns).
+// For deltas with absolute value larger than 35 minutes result is unspecified.
 inline constexpr int64_t ToNtpUnits(TimeDelta delta) {
   // For better precision `delta` is taken with best TimeDelta precision (us),
   // then multiplaction and conversion to seconds are swapped to avoid float
   // arithmetic.
-  return (delta.us() * (int64_t{1} << 32)) / 1'000'000;
+  // 2^31 us ~= 35.8 minutes.
+  return (rtc::saturated_cast<int32_t>(delta.us()) * (int64_t{1} << 32)) /
+         1'000'000;
 }
 
 // Converts interval from compact ntp (1/2^16 seconds) resolution to TimeDelta.
diff --git a/modules/rtp_rtcp/source/time_util_unittest.cc b/modules/rtp_rtcp/source/time_util_unittest.cc
index f77c3c6e5d..b3d557fd83 100644
--- a/modules/rtp_rtcp/source/time_util_unittest.cc
+++ b/modules/rtp_rtcp/source/time_util_unittest.cc
@@ -9,6 +9,10 @@
  */
 #include "modules/rtp_rtcp/source/time_util.h"
 
+#include <cstdint>
+#include <limits>
+
+#include "api/units/time_delta.h"
 #include "test/gtest.h"
 
 namespace webrtc {
@@ -109,6 +113,16 @@ TEST(TimeUtilTest, ToNtpUnits) {
   // 1 us ~= 4'294.97 NTP units. ToNtpUnits makes no rounding promises.
   EXPECT_GE(ToNtpUnits(TimeDelta::Micros(1)), 4'294);
   EXPECT_LE(ToNtpUnits(TimeDelta::Micros(1)), 4'295);
+
+  // Test near maximum and minimum supported values.
+  static constexpr int64_t k35MinutesInNtpUnits = int64_t{35 * 60} << 32;
+  EXPECT_EQ(ToNtpUnits(TimeDelta::Seconds(35 * 60)), k35MinutesInNtpUnits);
+  EXPECT_EQ(ToNtpUnits(TimeDelta::Seconds(-35 * 60)), -k35MinutesInNtpUnits);
+
+  // The result for too large or too small values is unspecified, but
+  // shouldn't cause integer overflow or other undefined behavior.
+  ToNtpUnits(TimeDelta::Micros(std::numeric_limits<int64_t>::max() - 1));
+  ToNtpUnits(TimeDelta::Micros(std::numeric_limits<int64_t>::min() + 1));
 }
 
 }  // namespace webrtc